Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retrograde transport: going against the flow

J M Lord1, L M Roberts

  • 1Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK.

Current Biology : CB
|March 21, 1998
PubMed
Summary

Certain protein toxins modify cellular substrates by entering the cytosol. These toxins utilize retrograde transport, moving from the cell surface through the Golgi complex to the endoplasmic reticulum.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased quadriceps intermuscular adipose tissue in chronic liver disease is associated with an altered muscle transcriptome compared with healthy age matched controls.

GeroScience·2025
Same author

A randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes.

Human reproduction (Oxford, England)·2025
Same author

Modelling the influence of vitamin D and probiotic supplementation on the microbiome and immune response.

Mathematical medicine and biology : a journal of the IMA·2024
Same author

Association of SARC-F Score and Rockwood Clinical Frailty Scale with CT-Derived Muscle Mass in Patients with Aortic Aneurysms.

The journal of nutrition, health & aging·2022
Same author

TANSLEY REVIEW No 3. THE STRUCTURE AND SYNTHESIS OF PLANT LECTINS.

The New phytologist·2021
Same author

Maternal macro- and micronutrient intake six months after hypertensive versus normotensive pregnancy: is poor diet quality contributing to future cardiometabolic disease risk?

Pregnancy hypertension·2021

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Toxicology

Background:

  • Protein toxins can enter mammalian cells and modify intracellular substrates.
  • Understanding the transport pathways of these toxins is crucial for cell biology and toxicology.

Purpose of the Study:

  • To elucidate the intracellular transport mechanism of protein toxins.
  • To identify the cellular compartments involved in toxin trafficking.

Main Methods:

  • The study likely involves tracking the movement of protein toxins within mammalian cells using various imaging and biochemical techniques.
  • Analysis of retrograde transport pathways, including the Golgi complex and endoplasmic reticulum.

Main Results:

  • Protein toxins are shown to enter the cytosol of mammalian cells.
  • The study confirms that toxins utilize retrograde transport for cellular entry.
  • The Golgi complex and endoplasmic reticulum are identified as key organelles in this pathway.

Conclusions:

  • Protein toxins employ a retrograde transport mechanism to reach the cytosol.
  • This pathway involves sequential movement from the cell surface to the endoplasmic reticulum via the Golgi complex.

Related Experiment Videos