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Related Experiment Videos

Nitric oxide may trigger lactation in humans

T Iizuka1, M Sasaki, K Oishi

  • 1Department of Pediatrics, Kihoku Hospital, Wakayama Medical College, Japan.

The Journal of Pediatrics
|January 15, 1998
PubMed
Summary
This summary is machine-generated.

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Nitric oxide (NO) is synthesized in the breast and may trigger human lactation. Measurements in breast milk showed NO markers correlated with milk volume, suggesting a key role in milk production.

Area of Science:

  • Reproductive biology
  • Biochemistry
  • Human physiology

Background:

  • Nitric oxide (NO) is a signaling molecule with diverse physiological roles.
  • Its potential involvement in lactation has not been previously established.

Purpose of the Study:

  • To investigate the synthesis of nitric oxide (NO) within the human breast.
  • To determine if NO plays a role in the process of lactation.

Main Methods:

  • Quantified biopterin, neopterin, and nitrite/nitrate concentrations in breast milk samples from 39 women.
  • Measured nitrite/nitrate levels in breast milk and serum from 17 women.

Main Results:

  • Nitrite/nitrate levels peaked before increased milk volume, indicating a temporal link to milk production.

Related Experiment Videos

  • Breast milk nitrite/nitrate correlated with milk volume, particularly in early postpartum days.
  • Higher nitrite/nitrate levels were observed in high milk-secreting women.

    • Conclusions:

    • Evidence suggests nitric oxide (NO) is synthesized in the breast.
    • NO may act as a trigger for initiating lactation in humans.