Related Experiment Video
Updated: Aug 6, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Differentiation antigens of the lymphocyte cell surface
Lymphocyte differentiation antigens, unique cell surface markers, were purified and characterized. These antigens are crucial for understanding lymphocyte function and developing targeted immunosuppressive therapies.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Background:
- Lymphocyte cell surfaces possess unique differentiation antigens not found on other tissues.
- These antigens mediate lymphocyte-specific functions and serve as markers for lymphoid cell types.
- They are potential targets for immunosuppressive anti-lymphocyte sera.
Purpose of the Study:
- To purify and characterize lymphocyte differentiation antigens.
- To enable discovery of their molecular properties.
- To develop specific antisera for functional studies and therapeutic applications.
Main Methods:
- Development and application of radioimmunoassays for analyzing anti-lymphocyte sera.
- Purification and characterization techniques for isolating specific antigens.
- Studies focused on rat lymphocyte differentiation antigens.
Main Results:
- Successful purification and characterization of the rat Thy-1 antigen.
- Preliminary studies on two additional rat lymphocyte differentiation antigens.
- Radioimmunoassays demonstrated advantages in antigen purification.
Conclusions:
- Purification of lymphocyte differentiation antigens is key to understanding their function.
- These antigens are valuable targets for immunosuppression and diagnostic tools.
- Further research on these antigens will advance immunology and therapeutic strategies.
More Related Videos
07:12Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
08:26The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
Published on: December 14, 2016
Related Concept Videos
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cells of the Adaptive Immune Response
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...