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Menstrual-linked asthma

A K Agarwal1, A Shah

  • 1Department of Clinical Research, Vallabhbhai Patel Chest Institute, University of Delhi, India.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|January 1, 1997
PubMed
Summary

Menstrual-linked asthma (MLA) affects about a fourth of female asthmatics in India, often indicating a more severe condition. These patients experience worse symptoms and require more medical intervention, particularly during their menstrual cycle.

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Area of Science:

  • Pulmonology
  • Gynecology
  • Women's Health

Background:

  • Asthma management in women requires understanding factors influencing symptom exacerbation.
  • Menstrual-linked asthma (MLA) is a recognized phenomenon, but its prevalence and characteristics in India require further investigation.

Purpose of the Study:

  • To determine the occurrence and characteristics of menstrual-linked asthma (MLA) in Indian female asthmatics of reproductive age.
  • To assess the relationship between MLA and asthma severity, healthcare utilization, and pulmonary function.

Main Methods:

  • A questionnaire-based study of 100 female asthmatics to identify subjective perception of asthma-menstrual cycle relationship.
  • Daily peak expiratory flow rate (PEFR) monitoring for 2 consecutive menstrual cycles in a subset of patients.
  • Correlation analysis between MLA, disease duration, symptom severity, and premenstrual syndrome (PMS).

Main Results:

  • Approximately 23% of female asthmatics reported MLA, with symptoms most commonly worsening during the premenstrual and menstrual weeks.
  • Patients with MLA exhibited significantly longer disease duration, more severe cough and breathlessness, and higher rates of emergency room visits and hospitalizations.
  • A significant decline in morning and evening PEFR values was observed during the premenstrual and menstrual weeks in MLA patients, indicating increased airway resistance.

Conclusions:

  • Menstrual-linked asthma (MLA) is present in about a fourth of female asthmatics in India and is associated with more severe disease.
  • MLA is linked to increased airway resistance, not just heightened symptom perception.
  • The findings highlight the importance of considering the menstrual cycle in the management of asthma in women.

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