Severe congenital neutropenia: a case study

Severe congenital neutropenia, or Kostmann syndrome, describes a rare autosomal recessive disorder in which the neutrophils fail to reach a mature and functional state. The infant with SCN often presents with severe infections beginning in the first month of life. Recently, treatment with recombinant granulocyte colony-stimulating factor has been found to be effective in reducing the mortality and morbidity of this often fatal disorder.