Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

External comparisons from nested case-control designs

S Suissa1, M D Edwardes, J F Boivin

  • 1Division of Clinical Epidemiology, Royal Victoria Hospital, Montréal, Québec, Canada.

Epidemiology (Cambridge, Mass.)
|January 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioglitazone and bladder cancer: improving research methods.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

A systematic review of observational studies of the association between pioglitazone use and bladder cancer.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Drospirenone-containing oral contraceptive pills and the risk of venous thromboembolism: a systematic review of observational studies.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Cardiotoxicity of aromatase inhibitors and tamoxifen in postmenopausal women with breast cancer: a systematic review and meta-analysis of randomized controlled trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Drospirenone-containing combined oral contraceptives and the risk of arterial thrombosis: a population-based nested case-control study.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

Risk factors for susceptibility to varicella in newly arrived adult migrants in Canada.

Epidemiology and infection·2013
Same journal

Application of the E-value under non-proportional hazards.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Can the All of Us sample be reweighted to mirror a nationally representative sample? A comparison of mortality predictors.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Gut health, systemic inflammation, and linear growth among Indonesian infants: findings from the Action Against Stunting Hub observation cohort: Erratum.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Evaluating Estimators in Partially Identified Models.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Stratification and accumulation? Explaining changing mortality inequities between business owners and non-owners in the U.S. (1984-2022).

Epidemiology (Cambridge, Mass.)·2026
Same journal

Be wary of age-stratum aging in early-onset cancer trends.

Epidemiology (Cambridge, Mass.)·2026
See all related articles

This study introduces new methods for using nested case-control designs in external comparisons, offering unbiased estimators for standardized mortality ratios. These novel approaches outperform traditional methods and provide insights into design efficiency based on exposure-follow-up time correlation.

Area of Science:

  • Epidemiology
  • Biostatistics
  • Health Research Methods

Background:

  • Nested case-control designs are typically used for internal comparisons within cohorts.
  • External comparisons using these designs have been limited, posing a challenge for accurate risk assessment.

Purpose of the Study:

  • To propose and evaluate probability-weighted estimators for external comparisons using nested case-control designs.
  • To compare the efficiency of nested case-control designs with case-cohort designs for external comparisons.

Main Methods:

  • Development of two probability-weighted estimators for nested case-control designs using external rates.
  • Calculation of confidence intervals for standardized mortality ratios using proposed estimators and their variances.
  • Computer simulations to examine the empirical properties of the estimators.

Related Experiment Videos

Main Results:

  • Proposed estimators are practically unbiased for external comparisons, unlike naive or Cox model-based estimators.
  • The efficiency of nested case-control versus case-cohort designs depends on the correlation between follow-up and exposure time.
  • A high correlation favors nested case-control designs, while a low correlation favors case-cohort designs.

Conclusions:

  • The proposed probability-weighted estimators provide a valid approach for external comparisons in nested case-control studies.
  • Design choice between nested case-control and case-cohort is critical and influenced by exposure-time dynamics.
  • The study validates the utility of nested case-control designs for external comparisons in epidemiological research.