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Alpha-interferon in the treatment of subacute sclerosing panencephalitis
M N Fayad1, B I Yamout, S Mroueh
1Department of Pediatrics, American University of Beirut Medical Center, Lebanon.
Abstract:
Subacute sclerosing panencephalitis is an inexorably progressive disease with no effective therapy. Recent trials of intrathecal and intraventricular alpha-interferon yielded controversial results. We tried intrathecal or intraventricular alpha-interferon in four patients with subacute sclerosing panencephalitis. None of them had evidence of improvement. We reviewed the previously published studies on the use of alpha-interferon in subacute sclerosing panencephalitis. Further international collaborative studies are needed to determine the role of alpha-interferon in the treatment of subacute sclerosing panencephalitis.
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