Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Oxidative stress and the brain]

M Tanaka1

  • 1Department of Neurology, Gunma University Faculty of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|February 12, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIIB fraction.

Cell·1992
Same author

A novel orally active inhibitor of IL-1 generation: synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives.

Journal of medicinal chemistry·1992
Same author

[An autopsy case of ACTH producing prostate neoplasms with Cushing's syndrome].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1992
Same author

Intraoperative endoscopic electrohydraulic lithotripsy of pancreatic stones.

International journal of pancreatology : official journal of the International Association of Pancreatology·1992
Same author

[A survey of body temperatures in the elderly and the thermal environment in nursing homes].

[Nihon koshu eisei zasshi] Japanese journal of public health·1992
Same author

Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities.

Chemical & pharmaceutical bulletin·1992
Same journal

[[Overview] Current status and challenges of ACP for older adults].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
Same journal

[Preface to the special issue on "Efforts for better advance care planning for older adults - Current situation and challenges in Japan"].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
Same journal

[Japan-multimodal intervention trial for prevention of dementia (J-MINT) and its societal implementation: Concepts, challenges, and future directions].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
Same journal

[Frontlines in geriatrics: Polypharmacy, the key revisions of the 2025 guidelines for medical treatment and its safety in the elderly].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
Same journal

[Erratum].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
Same journal

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
See all related articles

Oxidative stress and iron contribute to Parkinson's disease pathogenesis by promoting lipid peroxidation in neurons. Targeting iron or microglia may offer therapeutic benefits.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Context:

  • Parkinson's disease pathogenesis is not fully understood.
  • Oxidative stress is a suspected contributor.
  • Iron-dependent lipid peroxidation is implicated in neuronal death.

Purpose:

  • To investigate the role of iron-dependent lipid peroxidation in neuronal damage relevant to Parkinson's disease.
  • To explore mechanisms involving catechols, melanin, and microglia.

Summary:

  • Catechols and iron form oxidizing complexes, inducing lipid peroxidation (LPO) in neurons, independent of active oxygen species.
  • Synthetic melanin also promotes iron-dependent LPO, mediated by superoxide.
  • Microglia-derived superoxide and catechols release iron from ferritin, making it available for LPO, which destroys neuronal cells.

Related Experiment Videos

Impact:

  • Findings suggest that the substantia nigra's properties promote iron-dependent LPO.
  • Understanding iron-catechol-melanin-superoxide interactions is crucial.
  • Iron-chelating drugs or microglial modulators may alter Parkinson's disease progression.