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Dual respiratory virus infections

A L Drews1, R L Atmar, W P Glezen

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 7, 1998
PubMed
Summary

Dual respiratory virus infections (DRVI) occurred in 5% of cases, often in young children and those with chronic lung disease. DRVI patients were hospitalized more frequently than those with single virus infections.

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Area of Science:

  • Epidemiology
  • Virology
  • Infectious Diseases

Background:

  • Dual respiratory virus infections (DRVI) are increasingly recognized but require further characterization.
  • Understanding DRVI frequency, clinical impact, and risk factors is crucial for public health.
  • Immunocompetent individuals are susceptible to DRVI, necessitating comprehensive diagnostic approaches.

Purpose of the Study:

  • To determine the frequency and clinical significance of DRVI in immunocompetent individuals.
  • To identify associated comorbid conditions and clinical presentations of DRVI.
  • To assess the morbidity, including hospitalization rates, associated with DRVI.

Main Methods:

  • Retrospective review of eight prospective epidemiological studies (1991-1995).

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  • Analysis of 1,341 cases of acute respiratory virus infections.
  • Utilized cell culture, serology, and polymerase chain reaction (PCR) for viral detection.

    • Main Results:

    • DRVI accounted for 5.0% (67/1,341) of acute respiratory infections.
    • Children under 4 years old (42%) and individuals with chronic lung disease (58%) were frequently affected.
    • DRVI was linked to various respiratory illnesses, including pneumonia, asthma, and COPD exacerbations.
    • Hospitalization rates were significantly higher for DRVI patients (46.3%) compared to single-virus infections (21.7%).
    • Higher DRVI detection rates correlated with the combined use of multiple diagnostic methods.

    Conclusions:

    • DRVI is a significant contributor to respiratory illness morbidity in immunocompetent individuals.
    • Early and accurate diagnosis of DRVI is essential for effective patient management.
    • The incidence of DRVI may be underestimated without comprehensive diagnostic strategies.