Related Experiment Videos
Dynamics of some biochemical indices in myocardial infarction treated with thrombolysis and creatine phosphate
O Weinbergová1, K Zeman, J Komárek
1Department of Internal Medicine III, Faculty Hospital, Olomouc.
Insights
Creatine phosphate (Neoton) administration in myocardial infarction patients showed higher levels of cardiac enzymes like CK, AST, and LDH. This cardioprotective drug also shifted peak CK activity to earlier hours post-anginal pain onset.
Area of Science:
- Cardiology
- Biochemistry
- Pharmacology
Background:
- Myocardial infarction (MI) is a leading cause of mortality.
- Early detection and management of MI are crucial.
- Biochemical markers play a vital role in diagnosing and monitoring MI.
Purpose of the Study:
- To investigate the effect of intravenously administered creatine phosphate (Neoton) on biochemical indices in patients experiencing their first myocardial infarction.
- To assess the impact of Neoton on cardiac enzyme activity levels and timing post-MI onset.
Main Methods:
- A study involving 98 patients with their first myocardial infarction.
- Intravenous administration of creatine phosphate (Neoton).
- Monitoring of serum biochemical indices, including cardioselective enzyme activity, in treated patients compared to a control group.
Main Results:
- Patients treated with Neoton exhibited significantly higher serum levels of creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) compared to the control group.
- A notable shift in the peak activity of CK towards earlier hours after the onset of anginal pain was observed in the Neoton-treated group.
Conclusions:
- Intravenous creatine phosphate (Neoton) influences the serum levels and activity timing of key cardiac enzymes in acute myocardial infarction.
- These findings suggest Neoton's potential role in modulating the biochemical response to myocardial infarction, warranting further investigation into its cardioprotective mechanisms.
Abstract:
There was studied the effect of intravenously administered creatin phosphate (Neoton-drug with cardioprotective effect, Alfa Schiapparelli Wassermann) in the group of 98 patients affected by their first attack of myocardial infarction. In the course of the treatment there were observed the serum level of many biochemical indices, including the cardioselective enzyme activity. We concluded that the patients treated with Neoton, compared with the control group, revealed the significantly higher elevation of the CK, AST and LDH activity levels and the shift of the CK peak activity towards to the earlier hours after the onset of anginal pain.