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Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific
R L Ashley1, L Wu, J W Pickering
1Department of Laboratory Medicine, University of Washington, Seattle, USA. rashley@u.washington.edu
Journal of Clinical Microbiology
|February 12, 1998
Abstract:
A new commercial glycoprotein G-based enzyme immunoassay (gG-EIA) was compared with Western blotting (WB) for detection of herpes simplex virus type 1 (HSV-1) or HSV-2 type-specific antibodies in 193 serum samples. Sensitivity for HSV-1 was 95%; specificity was 96%. Sensitivity for HSV-2 was 98%; specificity was 97%. Twelve of 13 serum samples with equivocal gG-EIA results were serotyped by WB.