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[The diffusion and dissolution of metronidazole and doxepin in semisolid pharmaceutical forms through synthetic
M E Széliga1, M C Lamas, D A Lillo
1Dpto. Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Bollettino Chimico Farmaceutico
|July 1, 1997
Abstract:
The dissolution and diffussion methods through homogeneous synthetic membrane were studied in different semisolid topical formulations containing metronidazole and doxepin. The results suggest that the rate of release showed a first order kinetic for one of the formulations and the rate of release described by Higuchi for the others.