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Updated: Jul 31, 2026

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on (TRO) Approach
Published on: March 12, 2017
Terminating transcription in eukaryotes: lessons learned from RNA polymerase I
1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. rreeder@fhcrc.org
Abstract:
Within the past few years, the genes encoding transcription terminator proteins for RNA polymerase I (pol I) have been cloned from organisms as diverse as yeast and mammals. The availability of terminator proteins has allowed construction of in vitro transcription systems that terminate pol I at the same sites as used in vivo and thus allows study of termination mechanisms. This has resulted in a burst of information concerning pol I termination mechanisms, which this review will attempt to summarize.
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