[Interaction of sydnocarb with preparations influencing the metabolism of catecholamines]

Changes in the stimulating action of sydnocarbum and d,1-amphetamine on the locomotor activity of mice and conditioned reflexes of rats following introduction of reserpine, alpha-methyl-para-tyrosine (alpha-Mt) and nialamide were studied. The stimulating effect of sydnocarbum is in a great measure suppressed by reserpine, while that of amphetamine--by alpha-MT. Nialamide potentiates the stimulating action of both agents, the strengthening of the sydnocarbum effect, however, was more marked than that of amphetamine. The noted difference in the action of sydnocarbum and amphetamine was, possibly, due to the influence of the former chiefly on the stable, and of the second--on the labile neuronal norepinephrine depot.