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Related Experiment Videos

Biochemical detection of left-ventricular systolic dysfunction

T A McDonagh1, S D Robb, D R Murdoch

  • 1Cardiology Department, Western Infirmary, Glasgow, UK.

Lancet (London, England)
|January 20, 1998
PubMed
Summary

Plasma brain natriuretic peptide (BNP) levels can effectively screen for left-ventricular systolic dysfunction in the general population. Higher BNP concentrations were found in individuals with this cardiac condition, indicating its utility in early detection.

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Area of Science:

  • Cardiology
  • Biomarkers
  • Diagnostic Medicine

Background:

  • Previous studies on natriuretic peptides for left-ventricular systolic dysfunction detection may have been biased by higher cardiac disorder rates in control groups.
  • This study investigates plasma N-terminal atrial natriuretic peptide (NT-ANP) and brain natriuretic peptide (BNP) effectiveness in detecting left-ventricular systolic dysfunction.

Purpose of the Study:

  • To assess the diagnostic accuracy of NT-ANP and BNP in identifying left-ventricular systolic dysfunction within a general population sample.
  • To determine if these natriuretic peptides can detect the condition in both symptomatic and asymptomatic individuals.

Main Methods:

  • Randomly selected 2000 participants aged 25-74 years from Glasgow, UK.
  • 1653 respondents completed questionnaires and underwent echocardiography and electrocardiography.

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  • Plasma NT-ANP and BNP levels were measured using RIAs, with left-ventricular ejection fraction <= 30% defining left-ventricular systolic dysfunction.

    • Main Results:

    • 1252 participants had complete data for analysis.
    • Median NT-ANP and BNP concentrations were significantly higher in participants with left-ventricular systolic dysfunction (p < 0.001).
    • A BNP concentration of >= 17.9 pg/mL showed 77% sensitivity and 87% specificity for left-ventricular systolic dysfunction in all participants.

    Conclusions:

    • Plasma BNP measurement is a potentially cost-effective screening method for left-ventricular systolic dysfunction in the general population.
    • Targeted screening using BNP in high-risk individuals could enhance its effectiveness.
    • NT-ANP and BNP levels are elevated in both symptomatic and asymptomatic left-ventricular systolic dysfunction.