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Limiting dilution analysis of primary cytotoxic T-cell precursors
1Cancer Center, University of Rochester Medical Center, NY 14642, USA. mzauderer@cc.urmc.rochester.edu
Journal of Immunological Methods
|January 20, 1998
Abstract:
An efficient colorimetric assay has been adapted for limiting dilution analysis of cytotoxic T-cell precursors. Application of this assay in a suitable experimental model of thymic education could be especially useful in identifying factors that shape the CD8 T-cell repertoire. The essential elements of such a model are described here and elsewhere.