A meta-analysis of chromosome 18 linkage data for bipolar illness
Related Experiment Videos
D A Dorr1, J P Rice, C Armstrong
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Abstract:
We find a meta-data set (715 families, up to 1,124 sib pairs) for bipolar illness to have a strong signal in a 10 cM region around D18S40, and excess paternal sharing on the q arm near marker D18S64. We describe a method for meta-analysis of microsatellite marker data using affected sib-pair (ASP) methodology. Inherent difficulties in such analysis include heterogeneity of allele frequencies and protocol design, measurement errors in genotyping, and map construction. Using identity-by-descent (IBD) allele sharing as the dependent variable, a logistic regression to test for heterogeneity finds only mild heterogeneity, and a limited parent-of-origin effect.
Related Concept Videos
Bipolar Disorder
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Sex Linked Disorders
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Bulimia Nervosa
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...