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Assessing linkage on chromosome 5 using components of variance approach: univariate versus multivariate
M de Andrade1, T J Thiel, L Yu
1Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030-4095, USA.
Abstract:
We report results when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.