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Factors influencing the identification of major genes in a complex disease genome scan
H Yang1, Y Wang, D R Goldstein
1Division of Medical Genetics, Cedars-Sinai Research Institute, School of Medicine, UCLA, USA.
Genetic Epidemiology
|January 1, 1997
Abstract:
A two-stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of several approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertaining through multiple affected family members, increasing the sample size, and using multipoint linkage analysis.