Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees

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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

J Graham1, N H Chapman, K A Goddard

  • 1Department of Biostatistics, University of Washington, Seattle 98195-7720, USA.

Genetic Epidemiology
|January 1, 1997
PubMed

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Pedigree Analysis02:21

Pedigree Analysis

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Pedigree Analysis02:21

Pedigree Analysis

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Dihybrid Crosses

To determine whether traits are inherited together or separately, Gregor Mendel crossed pea plants that differed in two traits. These parental plants were homozygous for both traits but displayed different phenotypes. The first generation of offspring were all dihybrids, heterozygotes exhibiting the two dominant phenotypes. When self-fertilized, the dihybrids consistently produced progeny with a 9:3:3:1 ratio of four possible phenotype combinations. This ratio suggested that inheriting one...
Dihybrid Crosses01:22

Dihybrid Crosses

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While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.Let’s think of two homozygous...