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Optimizing growth hormone therapy during puberty

E Codner1, V Mericq, F Cassorla

  • 1Institute of Maternal and Child Research, University of Chile, School of Medicine, Casilla, Santiago.

Hormone Research
|January 1, 1997
PubMed
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Children with growth hormone (GH) deficiency face challenges during puberty. This review examines strategies like increased GH dosage or LHRH analogs to improve growth spurts and final height, though efficacy needs further demonstration.

Area of Science:

  • Pediatric Endocrinology
  • Hormone Therapy
  • Adolescent Growth

Background:

  • Children with growth hormone (GH) deficiency often struggle with pubertal growth spurts.
  • Puberty involves complex hormonal interactions critical for development.
  • Optimizing growth hormone therapy during this period is a key clinical challenge.

Purpose of the Study:

  • To review hormonal interactions during puberty in GH-deficient children.
  • To examine therapeutic strategies for optimizing GH therapy during puberty.
  • To assess the demonstrated efficacy of these strategies on final height.

Main Methods:

  • Review of existing literature on hormonal changes during puberty.
  • Analysis of two primary therapeutic approaches for GH-deficient children.

Related Experiment Videos

  • Evaluation of studies assessing the impact of these strategies on final height.

    • Main Results:

    • Two main strategies exist: increasing GH dose or combining GH with LHRH analogs.
    • Increased GH dosage aims to replicate physiological pubertal GH surges.
    • LHRH analogs are used to delay epiphyseal fusion, extending the growth period.

    Conclusions:

    • Current therapeutic strategies for GH-deficient children during puberty include dose adjustments and LHRH analog co-administration.
    • The effectiveness of these interventions in significantly increasing final height requires clearer demonstration.
    • Further research is needed to establish optimal treatment protocols for maximizing growth outcomes.