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Somatopause and adiposity

J O Jørgensen1, N Vahl, S Fisker

  • 1Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark. JOJ@afdm.aau.dk

Hormone Research
|January 1, 1997
PubMed
Summary

Growth hormone (GH) mobilizes lipids. Declining GH and increased abdominal fat with aging may form a vicious cycle, impacting metabolism and lipolytic response.

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Area of Science:

  • Endocrinology
  • Metabolism
  • Aging Research

Background:

  • Growth hormone (GH) is crucial for lipid mobilization.
  • Ageing is associated with declining GH levels and increased body fat.
  • The relationship between GH, aging, and fat accumulation requires further investigation.

Purpose of the Study:

  • To explore the interplay between GH, abdominal fat, and aging.
  • To investigate the impact of aging on GH release, clearance, and lipolytic response.
  • To propose a mechanism for age-related fat accumulation involving GH.

Main Methods:

  • Cross-sectional analysis of GH release and abdominal fat.
  • Assessment of metabolic clearance rate and distribution volume of GH.
  • Evaluation of lipolytic response to GH in different age groups.

Main Results:

  • Abdominal fat significantly predicts both spontaneous and stimulated GH release.
  • Aging increases GH metabolic clearance and distribution volume, correlating with fat mass.
  • Older adults and women exhibit a reduced acute lipolytic response to GH.

Conclusions:

  • Lifestyle and dietary changes, coupled with reduced GH lipolytic sensitivity, may initiate age-related fat accumulation.
  • Increased fat mass further suppresses GH release and accelerates its clearance, creating a detrimental cycle.
  • Understanding this GH-fat-aging axis is key to addressing metabolic changes in aging populations.

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