Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proline specific peptidases

D F Cunningham1, B O'Connor

  • 1School of Biological Sciences, Dublin City University, Dublin, Ireland.

Biochimica Et Biophysica Acta
|January 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

A nearby long gamma-ray burst from a merger of compact objects.

Nature·2022
Same author

Impact of "early intervention" parent workshops on outcomes for caregivers of children with neurodisabilities: a mixed-methods study.

Disability and rehabilitation·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Referral, Assessment and Use of Screening Measures Related to Autism Spectrum Disorder at a Tertiary Hospital Setting.

Journal of autism and developmental disorders·2020
Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019
Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019
Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019
See all related articles

Proline-specific peptidases are crucial enzymes that hydrolyze peptide bonds at proline sites. Understanding these enzymes and their roles in physiological and disease states is vital.

Area of Science:

  • Biochemistry
  • Enzymology
  • Structural Biology

Background:

  • Proline's unique cyclic structure impacts peptide and protein conformation and biological activity.
  • Specific enzymes, peptidases, have evolved to recognize and process proline residues in biomolecules.

Purpose of the Study:

  • To discuss enzymes that hydrolyze peptide bonds at proline sites.
  • To detail the discovery, biochemical attributes, substrate specificities, and physiological roles of these proline-specific peptidases.

Main Methods:

  • Review of literature on proline-specific peptidases.
  • Analysis of biochemical properties and substrate specificities.
  • Description of methodologies for enzyme detection and activity manipulation.

Related Experiment Videos

Main Results:

  • Proline-specific peptidases are essential for processing proline-containing substrates.
  • These enzymes exhibit diverse biochemical attributes and substrate specificities.
  • Their physiological roles and involvement in disease states are elucidated.

Conclusions:

  • Proline-specific peptidases are critical in biological systems.
  • Dysfunction of these enzymes is linked to various disease states.
  • Further research into these enzymes holds therapeutic potential.