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Cloning of a T-cell receptor beta-chain enhancer binding protein
1La Jolla Institute for Allergy and Immunology, Department of Molecular Biology, San Diego, CA 92122, USA. jgaikwad@mail.db.uth.tmc.edu
Gene
|January 20, 1998
Abstract:
Several eukaryotic DNA binding proteins have been isolated by screening lambda expression libraries with DNA probes containing their binding site. This strategy has been employed to isolate clones of the factor that interacts with the T-cell receptor beta-chain enhancer motif. A cDNA clone encoding a protein similar to YB-1 has been isolated with this. It seems probable that this protein YB, might interact with other proteins and regulate the transcription of the T-cell receptor beta-chain gene.