Related Experiment Video
Updated: Aug 9, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Analysis of the Smad2 gene in hematological malignancies
T Ikezoe1, S Takeuchi, M Kamioka
1Department of Internal Medicine, Kochi Medical School, Nankoku, Japan.
Abstract:
A total of 34 leukemia and lymphoma samples (17 clinical samples and 17 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation polymorphism (RT-PCR-SSCP) analysis. Nine of the 34 samples had 18q chromosomal abnormalities. No shifted bands were detected in any of the hematological malignancies. Our results suggest that resistance to cell growth inhibitory effects of TGF-beta in hematological malignancies is not due to alterations of the Smad2 gene.
More Related Videos
Related Concept Videos
Abnormal Proliferation
Regulation of Hematopoietic Stem Cells

