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Related Experiment Videos

CD44 expression in astrocytic tumors

L R Ylagan1, B Quinn

  • 1New York University Medical Center, Department of Pathology, New York, USA.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|January 22, 1998
PubMed
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Standard CD44 (CD44s) expression does not differentiate between low- and high-grade astrocytomas. This adhesion molecule is not a reliable clinical marker for distinguishing glioma grades, necessitating exploration of other factors.

Area of Science:

  • Neuro-oncology
  • Cell Adhesion Molecules
  • Cancer Biomarkers

Background:

  • CD44 is an adhesion molecule found on various cells, implicated in cancer prognosis and metastasis.
  • CD44 has been suggested as an invasion marker for glioblastoma.
  • The role of standard CD44 (CD44s) in differentiating astrocytoma grades requires further investigation.

Purpose of the Study:

  • To determine if standard CD44 (CD44s) can serve as a clinically useful marker to distinguish between low- and high-grade astrocytomas.
  • To evaluate the correlation of CD44s expression with tumor grade in astrocytic tumors.
  • To investigate the expression of variant CD44 (CD44v) in gliomas.

Main Methods:

  • Immunohistochemical staining of CD44s and glial fibrillary acidic protein (GFAP) on 75 astrocytic tumors (JPA, LGA, AA, GBM).

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  • Evaluation of CD44s expression using a three-tiered intensity scale by two observers.
  • Testing a subset of gliomas for CD44v expression using specific monoclonal antibodies.

    • Main Results:

    • High expression of CD44s (2+ or 3+ intensity) was observed in 89% of JPAs, 90% of LGAs, 76% of AAs, and 84% of GBMs.
    • No significant difference in CD44s staining intensity was found between low- and high-grade gliomas (P > .05).
    • Some anaplastic tumors were negative for CD44s, and gliomas were immunonegative for CD44v6.

    Conclusions:

    • Standard CD44 (CD44s) expression does not correlate with the grade of astrocytomas.
    • CD44s is not a reliable biomarker for distinguishing between low- and high-grade gliomas.
    • Further research into other molecular factors is needed to understand the differential behavior of astrocytoma grades, especially given the absence of CD44v expression in gliomas.