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A re-analysis of a randomized clinical trial for gastric cancer using interval censoring
J Sakamoto1, S Teramukai, H Nakazato
1Department of Surgery, Aichi Prefectural Hospital, Japan.
Abstract:
In a previous randomized clinical trial against curatively resected gastric cancer, we compared the effect of immunochemotherapy to chemotherapy and obtained significantly better survival and disease-free survival time (DFS) in a combined therapy group. Although DFS was analysed with a conventional approach in which the onset of relapse was defined as the diagnosis of relapse, we considered it necessary to re-analyse the data and compare the results of an interval-censored approach with the conventional approach, in order to examine whether the conclusion might be altered depending on the approach.
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