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Bacteriology of chronic sinusitis after ampicillin therapy
1Department of Otolaryngology, Taichung Veterans General Hospital, Taiwan, Republic of China.
American Journal of Rhinology
|January 23, 1998
Summary
Preoperative ampicillin reduced bacterial cultures in chronic sinusitis patients. However, resistant bacteria persisted in maxillary and ethmoid sinuses, indicating limited antibiotic efficacy.
Area of Science:
- Otolaryngology
- Microbiology
- Pharmacology
Background:
- Chronic sinusitis is a common condition often treated with antibiotics.
- Understanding the impact of preoperative antibiotic use on sinus microbiome is crucial for treatment optimization.
Purpose of the Study:
- To investigate the effect of ampicillin on bacterial colonization in maxillary and ethmoid sinuses of chronic sinusitis patients.
Main Methods:
- Bacterial cultures were obtained from 74 chronic sinusitis patients undergoing functional endoscopic sinus surgery.
- Patients received ampicillin (500 mg every 6 hours) for 2 weeks preoperatively.
- Culture rates and antibiotic sensitivity were analyzed.
Main Results:
- Ampicillin significantly decreased culture rates in both maxillary (46.0%) and ethmoid (41.9%) sinuses compared to non-antibiotic treated groups.
- However, ampicillin sensitivity was low: 23.7% in maxillary and 5.9% in ethmoid sinuses.
- Resistant bacteria were found to persist despite ampicillin treatment.
Conclusions:
- Preoperative ampicillin can reduce bacterial load in chronic sinusitis.
- The persistence of ampicillin-resistant bacteria highlights the need for careful antibiotic selection and stewardship.