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Related Experiment Videos

Antimicrobial effect on rabbit sinusitis after temporary ostial occlusion

D J Beste1, D T Capper, K Shaffer

  • 1Department of Otolaryngology and Human Communication, Medical College of Wisconsin, Milwaukee 53226, USA.

American Journal of Rhinology
|January 23, 1998
PubMed
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Relief of sinus ostial obstruction, not antibiotics, significantly resolves acute bacterial sinusitis (ABS) in a rabbit model. Ostial patency is crucial for sinusitis resolution and mucosal swelling reduction.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Ostiomeatal obstruction is a key factor in acute bacterial sinusitis (ABS) pathogenesis.
  • Sinusitis resolution is thought to depend on sinus ostium patency.

Purpose of the Study:

  • To quantify sinusitis resolution after temporary ostial occlusion in a rabbit model.
  • To quantify bacterial clearance with and without antimicrobial therapy in Staphylococcus aureus infected sinuses.

Main Methods:

  • A blinded, placebo-controlled study in 10 rabbits.
  • Temporary maxillary sinus ostial obstruction using Merocel.
  • Computerized tomography (CT) imaging and sinus cultures before and after occlusion/removal.

Main Results:

Related Experiment Videos

  • Mean CT sinusitis scores increased with ostial obstruction and decreased with ostial plug removal (P < 0.0001 and P < 0.001).
  • Staphylococcus aureus injection did not significantly alter CT scores.
  • Antimicrobial therapy did not significantly reduce CT scores or positive cultures.

Conclusions:

  • Resolution of mucosal swelling in sinusitis is more dependent on relieving ostial obstruction than on antimicrobial therapy.
  • Temporary ostial occlusion and subsequent relief are critical factors in sinusitis resolution.