Remote functionalization of the steroid side-chain
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Updated: Oct 30, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
E J Parish1, N Aksara, T L Boos
1Department of Chemistry, Auburn University, Alabama 36849, USA. parisej@mail.auburn.edu
Abstract:
By using classical methods of organic synthesis, the introduction of chemical modifications into the saturated side-chains of steroids usually requires a multistep synthesis to construct new side-chains to be added to the steroid nucleus. In order to circumvent these earlier methods, new procedures have been developed to directly introduce functionality onto the steroid side-chain to produce useful products. These initial products may also provide an entry toward the further modification of the side-chain to produce steroids which could previously be obtained only with great difficulty.
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