Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Molecules in focus: tenascin-C

¹Department of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.

The International Journal of Biochemistry & Cell Biology

|January 23, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6.

Bone reports·2021

Same author

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs.

Matrix biology : journal of the International Society for Matrix Biology·2019

Same author

Subchondral bone microdamage accumulation in distal metacarpus of Thoroughbred racehorses.

Equine veterinary journal·2018

Same author

Prevalence of subchondral bone pathological changes in the distal metacarpi/metatarsi of racing Thoroughbred horses.

Australian veterinary journal·2017

Same author

Role of subchondral bone remodelling in collapse of the articular surface of Thoroughbred racehorses with palmar osteochondral disease.

Equine veterinary journal·2015

Same author

Thoroughbred horses in race training have lower levels of subchondral bone remodelling in highly loaded regions of the distal metacarpus compared to horses resting from training.

Veterinary journal (London, England : 1997)·2014

Tenascin-C, an extracellular matrix glycoprotein, is involved in development and disease. Its selective expression in tumors shows promise for targeted cancer therapy using radio-labeled antibodies.

Area of Science:

Biochemistry
Cell Biology
Oncology

Background:

Tenascin-C is a hexameric extracellular matrix glycoprotein with diverse isoforms.
It is synthesized during development and in pathological conditions in the nervous system, vasculature, and connective tissues.
Expression is induced by growth factors like transforming growth factor-beta and interleukin-1, and it is generally anti-adhesive.

Purpose of the Study:

To explore the role and therapeutic potential of Tenascin-C.

Main Methods:

Analysis of Tenascin-C synthesis and expression patterns.
Investigation of its influence on cell differentiation.
Development of radio-labelled monoclonal anti-Tenascin-C antibodies for tumor targeting.

Related Experiment Videos

Main Results:

Tenascin-C expression is induced by specific factors and occurs in key tissues during development and pathology.
Despite being anti-adhesive, it influences cell differentiation.
Radio-labeled anti-Tenascin-C antibodies have shown promising results in clinical trials for tumor targeting.

Conclusions:

Tenascin-C plays a significant role in biological development and disease states.
Its selective expression in tumors makes it a viable target for novel cancer therapies.
Anti-Tenascin-C antibody-based therapies demonstrate potential for effective tumor treatment.