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Right ventricular regional function using MR tagging: normals versus chronic pulmonary hypertension
Z A Fayad1, V A Ferrari, D L Kraitchman
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA.
Magnetic Resonance in Medicine
|January 23, 1998
Summary
Regional right ventricular (RV) function is often unclear. This study shows MR tagging can measure RV regional shortening, revealing reduced function in pulmonary hypertension patients, especially in the RV outflow tract.
Area of Science:
- Cardiovascular imaging
- Cardiac MRI
- Pulmonary hypertension research
Background:
- Right ventricular (RV) regional function is poorly understood in both healthy individuals and patients with cardiovascular disease.
- Accurate assessment of RV performance is crucial for diagnosing and managing conditions like pulmonary hypertension.
Purpose of the Study:
- To noninvasively assess regional right ventricular (RV) function using 1D MR myocardial tagging.
- To compare RV regional function in healthy subjects versus patients with chronic pulmonary hypertension.
Main Methods:
- Utilized 1D MR myocardial tagging to measure intramyocardial segmental shortening in the RV and septum.
- Evaluated ten healthy subjects and seven patients with chronic pulmonary hypertension.
Main Results:
- Normal RV free wall shortening was non-uniform, increasing from the outflow tract to the apex.
- RV free wall long-axis shortening exhibited a complex pattern.
- Pulmonary hypertension patients showed globally reduced regional short- and long-axis shortening, most notably in the RV outflow tract and basal septum.
Conclusions:
- MR tagging provides quantitative evaluation of regional RV function.
- Chronic pulmonary hypertension significantly impairs RV regional performance, particularly in specific areas.
- This technique can determine the impact of pulmonary hypertension on RV function.