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Gentamicin-induced Bartter-like syndrome

D Landau¹, K K Kher

¹Department of Pediatrics, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University in Negev, Beer Sheva, Israel.

Pediatric Nephrology (Berlin, Germany)

|January 23, 1998

Summary

Gentamicin can cause kidney damage, including a Bartter-like syndrome in children. This condition, characterized by electrolyte imbalances, resolved in all patients after discontinuing gentamicin.

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Area of Science:

Pediatric Nephrology
Clinical Toxicology

Background:

Gentamicin is a common antibiotic known for potential nephrotoxicity.
Bartter-like syndrome, a form of renal tubulopathy, has been documented in adults receiving gentamicin but is poorly characterized in children.

Observation:

This report details four pediatric cases of gentamicin-associated Bartter-like syndrome.
Patients aged 4 months to 17 years exhibited distal nephron tubulopathy.

Findings:

Key manifestations included hypocalcemia, hypomagnesemia, metabolic alkalosis, and hypokalemia.
All patients demonstrated complete recovery of renal tubular function and electrolyte balance upon gentamicin cessation.

Implications:

Gentamicin-induced Bartter-like syndrome is a reversible nephrotoxic effect in children.
Awareness of this syndrome is crucial for pediatricians managing gentamicin therapy.

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