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Dopamine receptor agonists alter gap prestimulus modulation

D S Leitner1, E M Girten

  • 1Department of Psychology, Saint Joseph's University, Philadelphia, PA 19131-1395, USA.

Psychopharmacology
|January 23, 1998
PubMed
Summary
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Dopamine D2 receptor agonists modulate the startle reflex inhibition in rats. Quinpirole enhanced this inhibition, particularly with longer silent prepulses, suggesting a role for D2 receptors in sensory gating.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Auditory Neuroscience

Background:

  • Prestimulus inhibition of the acoustic startle reflex (ASR) is a basic form of sensory gating.
  • Dopamine pathways are implicated in attention and sensory processing.

Purpose of the Study:

  • To investigate the role of dopamine D1 and D2 receptors in the inhibition of the rat's acoustic startle reflex by brief silent periods (gaps).
  • To examine the effects of a D1 agonist (SKF-38393) and a D2 agonist (quinpirole) on gap inhibition.

Main Methods:

  • Rats were exposed to continuous noise with brief silent gaps preceding a startle-eliciting stimulus.
  • The effects of varying doses of quinpirole and SKF-38393 on gap inhibition were measured.
  • The D2 antagonist haloperidol was used to assess the involvement of D2 receptors.

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Main Results:

  • Quinpirole exhibited a biphasic effect on gap inhibition, with lower doses increasing inhibition and higher doses showing dose-dependent effects based on gap duration.
  • SKF-38393 had no significant effect on gap inhibition.
  • Haloperidol reversed the enhancing effect of quinpirole on gap inhibition.

Conclusions:

  • The dopamine D2 receptor group plays a significant role in modulating gap inhibition of the acoustic startle reflex.
  • These findings suggest that D2 receptor agonists may influence attention-related sensory gating mechanisms.