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Hypersensitivity to acid in ulcer-like functional dyspepsia
The Korean Journal of Internal Medicine
|June 1, 1997
Summary
Patients with ulcer-like functional dyspepsia may experience pain due to acid hypersensitivity. This study found that direct acid administration triggered pain in these patients, unlike healthy controls, suggesting a role for acid in their discomfort.
Area of Science:
- Gastroenterology
- Pain Perception
- Functional Gastrointestinal Disorders
Background:
- The mechanism of pain in ulcer-like functional dyspepsia remains unclear.
- Current treatments often focus on acid suppression, but the role of acid itself is unknown.
Purpose of the Study:
- To investigate the role of acid hypersensitivity in pain sensation in ulcer-like functional dyspepsia.
- To directly assess the effect of gastric acid administration on pain perception.
Main Methods:
- A study involving 12 patients with ulcer-like functional dyspepsia and 7 healthy controls.
- Nasogastric administration of normal saline or 0.1N hydrochloric acid in a blinded, cross-over manner.
- Pain assessment based on patient-reported symptoms similar to their usual condition.
Main Results:
- 41.7% of patients with ulcer-like functional dyspepsia developed pain upon administration of 0.1N hydrochloric acid.
- No patients experienced pain with normal saline administration.
- Healthy controls did not develop pain with either saline or acid administration.
Conclusions:
- Acid hypersensitivity appears to play a significant role in the pain experienced by patients with ulcer-like functional dyspepsia.
- These findings suggest a potential mechanism for pain in this condition.