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Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C
T J Heigle1, R D Stulting, D A Palay
1Bascom Palmer Eye Institute, Emory University, Atlanta, GA 30322, USA.
Purpose:
To study the effect of topical mitomycin C on conjunctival squamous neoplasia.
Methods:
Three patients with recurrent conjunctival epithelial neoplasia were treated with topical mitomycin C 0.04%.
Results:
Six to 9 months after treatment, no patient had clinical evidence of tumor recurrence. Conjunctival biopsy in two patients and cytology in one patient showed no evidence of tumor 1 to 4 months after treatment. One patient required short-term treatment for corneal edema and epithelial toxicity.
Conclusion:
Topical mitomycin C caused tumor regression without recurrence for 6 to 9 months after treatment.
