Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Double trisomy in spontaneous abortions

K S Reddy1

  • 1Cytogenetics Laboratory, Quest Diagnostics, San Juan Capistrano, CA 92690-6130, USA.

Human Genetics
|January 24, 1998
PubMed
Summary

This study analyzed 3,034 spontaneous abortions over 10 years, finding 22 double trisomy cases. Higher maternal age and earlier gestational age were linked to double trisomies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of meteorological variability with sesame yield in semi-arid Bundelkhand region of India.

Scientific reports·2026
Same author

Floral and pollination biology of dragon fruit reveals strategies for enhancing productivity through pollination management and reproductive window extension.

Scientific reports·2025
Same author

Innovative and polygonal trend analysis of temperature in agro climatic zones of India.

Scientific reports·2024
Same author

Health effects of selected environmental Exposomes Across the Life courSe in Indian populations using longitudinal cohort studies: GEOHealth HEALS Study protocol.

BMJ open·2024
Same author

India led health innovation(s) for achieving the SDG health goal in the global South.

Perspectives in public health·2022
Same author

COVID-19: Impact analysis and recommendations for power sector operation.

Applied energy·2020

Area of Science:

  • Reproductive genetics
  • Human genetics
  • Cytogenetics

Background:

  • Spontaneous abortions are common, with chromosomal abnormalities being a leading cause.
  • Understanding the spectrum of aneuploidies, including complex ones like double trisomies, is crucial for reproductive health.
  • Cytogenetic analysis of products of conception provides insights into early pregnancy loss.

Purpose of the Study:

  • To review and analyze cytogenetic data of spontaneous abortions over a decade.
  • To identify and characterize cases of double trisomy and other complex aneuploidies.
  • To investigate potential associations between double trisomy and maternal/gestational age.

Main Methods:

  • Karyotyping of 3,034 products of conception from spontaneous abortions between 1986 and 1997.
  • Analysis of tissues including sac, villi, and placenta.
  • Statistical comparison of maternal age and gestational age between single and double trisomy cases.

Main Results:

  • Twenty-two cases of double trisomy, one triple trisomy, and one trisomy/monosomy mosaic were identified.
  • Chromosomes 16, 8, 15, 2, 13, and 21 were most frequently involved in double trisomies.
  • Double trisomy cases showed significantly higher mean maternal age (34.1 years) and lower mean gestational age (8.7 weeks) compared to single trisomies.

Conclusions:

  • Double trisomies represent a significant portion of complex aneuploidies in spontaneous abortions.
  • Maternal age is a significant risk factor for double trisomy.
  • Complex aneuploidies are associated with earlier embryonic demise.

Related Experiment Videos