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Related Experiment Videos

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing

J F Flood1, K Uezu, J E Morley

  • 1Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63106, USA. jff31545@aol.com

Brain Research
|January 24, 1998
PubMed
Summary

Cortistatin-14, a neuropeptide, impairs memory retention in mice. This study found that intracerebroventricular injections of cortistatin-14 negatively affected the recall of learned avoidance behaviors.

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Area of Science:

  • Neuroscience
  • Neuropharmacology
  • Behavioral Neuroscience

Background:

  • Cortistatin-14 is a neuropeptide found in the brain's cortex and hippocampus.
  • In the hippocampus, it inhibits neuronal firing and is co-localized with GABA.

Purpose of the Study:

  • To investigate the effect of cortistatin-14 on memory retention.
  • To determine if cortistatin-14 administration impairs the recall of learned behaviors.

Main Methods:

  • CD-1 mice underwent footshock avoidance training.
  • Intracerebroventricular injections of either saline or cortistatin-14 were administered post-training.
  • Memory retention was assessed one week later by resuming training.

Main Results:

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  • Cortistatin-14 administration resulted in impaired memory retention compared to the saline control group.
  • This impairment was observed at doses ranging from 0.5 to 5.0 micrograms.

Conclusions:

  • Cortistatin-14 negatively impacts memory retention in mice.
  • These findings suggest a role for cortistatin-14 in modulating cognitive functions, specifically memory recall.