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Related Experiment Videos

Mitogens as motogens

M R Chicoine1, D L Silbergeld

  • 1Washington University School of Medicine, Department of Neurological Surgery, St. Louis, MO 63110-1093, USA.

Journal of Neuro-Oncology
|January 24, 1998
PubMed
Summary

This review details methods for studying glioma cell invasion and motility. It examines how growth factors and cytokines influence cancer cell movement in vitro and in vivo.

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Area of Science:

  • Neuroscience
  • Oncology
  • Cell Biology

Background:

  • Glioma cell invasion is a key factor in brain tumor progression.
  • Understanding glioma cell motility is crucial for developing effective treatments.

Purpose of the Study:

  • To review and summarize methodologies for assessing glioma cell invasion and motility.
  • To present the role of specific mitogens and cytokines in influencing glioma cell movement.

Main Methods:

  • In vivo studies documenting glioma cell invasion through brain parenchyma.
  • In vitro assays including Boyden chambers, chemotaxis assays, and time-lapse microscopy.
  • Quantitative enzyme immunoassays for invasion-associated proteins and cytokine-mediated effects on motility.

Main Results:

  • Various techniques effectively assess random and directional glioma cell motility.
  • Specific cytokines like epidermal growth factor (EGF) and tumor necrosis factor alpha (TNF alpha) impact glioma cell motility.
  • Mitogens can act as motogens, influencing cell movement.

Conclusions:

  • A comprehensive understanding of glioma cell motility requires diverse in vivo and in vitro methodologies.
  • Cytokines play a significant role in regulating glioma cell invasion and migration.
  • Further research into mitogen-driven motility can inform therapeutic strategies.

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