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Neurotrophins in cerebellar granule cell development and medulloblastoma
S L Pomeroy1, M E Sutton, L C Goumnerova
1Department of Neurology, Children's Hospital, Boston, MA, USA.
Journal of Neuro-Oncology
|January 24, 1998
Abstract:
Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.