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Related Experiment Videos

Human papillomaviruses and associated malignancies

R M Alani1, K Münger

  • 1Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02115, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|January 24, 1998
PubMed
Summary

Human papillomaviruses (HPVs) are linked to epithelial cancers, especially cervical carcinoma. Understanding HPV oncogenes like E6 and E7 is key to developing targeted therapies for HPV-associated malignancies.

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Area of Science:

  • Virology
  • Oncology
  • Molecular Biology

Background:

  • Human papillomaviruses (HPVs) are DNA tumor viruses infecting epithelial cells, causing proliferative lesions.
  • Epidemiologic and experimental data implicate specific HPVs in epithelial malignancies, with >90% of cervical carcinomas testing positive for HPV.
  • High-risk mucosal HPV subtypes are primarily responsible for these lesions.

Purpose of the Study:

  • To review the basic biologic properties of HPVs.
  • To elucidate the mechanisms of cellular transformation by malignancy-associated HPV subtypes.
  • To discuss HPV oncogenes (E6 and E7) and their role in carcinogenesis.

Main Methods:

  • Review of existing epidemiologic data.
  • Analysis of in vitro and in vivo studies.

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  • Discussion of molecular mechanisms of HPV-associated carcinogenesis.

    • Main Results:

    • Significant advances in understanding HPV biology, though propagation in culture was a historical challenge.
    • Detailed examination of HPV oncogenes E6 and E7.
    • Association of HPV infections with premalignant and malignant disorders of squamous and mucosal epithelia.

    Conclusions:

    • HPV infection is a major cause of cervical carcinogenesis.
    • Understanding HPV-related cellular dysregulation informs potential targeted molecular therapies.
    • Further research into HPV-associated malignancies in various hosts is warranted.