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Related Experiment Videos

Magnetization transfer with echo planar imaging

J P Ranjeva1, J M Franconi, C Manelfe

  • 1Department of Neuroradiology, University Hospital Purpan, Toulouse, France.

Magma (New York, N.Y.)
|January 24, 1998
PubMed
Summary
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Magnetization transfer (MT) imaging can now be achieved rapidly using echo planar imaging (EPI) with optimized radiofrequency pulse trains. This technique enhances the characterization of multiple sclerosis lesions.

Area of Science:

  • Magnetic Resonance Imaging
  • Biophysics
  • Medical Physics

Background:

  • Magnetization transfer (MT) aims to saturate macromolecule protons, creating signal differences in free water pools.
  • Achieving MT contrast with echo planar imaging (EPI) is challenging due to single saturation pulse limitations.
  • EPI's short acquisition time is advantageous for MT imaging.

Purpose of the Study:

  • To optimize an EPI clinical sequence for improved MT contrast sensitivity.
  • To investigate the influence of radiofrequency (RF) pulse train parameters on MT rate.
  • To enable rapid MT mapping for clinical applications.

Main Methods:

  • Implementing a train of multiple RF saturation pulses before EPI acquisition.
  • Systematically varying RF pulse train parameters to optimize MT rate.

Related Experiment Videos

  • Acquiring MT maps within approximately 1 second.

    • Main Results:

    • The optimized RF pulse train significantly improves EPI sensitivity to MT.
    • The developed technique allows for rapid MT map generation.
    • The method demonstrates effectiveness in characterizing multiple sclerosis lesions.

    Conclusions:

    • Optimized RF pulse trains enhance MT contrast in EPI.
    • Rapid MT mapping using EPI is feasible and beneficial for clinical use.
    • This technique aids in the characterization of neurological conditions like multiple sclerosis.