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Related Experiment Videos

Bioabsorbable and biodegradable stents in urology

M Talja1, T Välimaa, T Tammela

  • 1Päijät-Häme Central Hospital, Surgical Department, Lahti, Finland.

Journal of Endourology
|January 24, 1998
PubMed
Summary

Bioabsorbable spiral stents made from polyglycolide and polylactide offer novel solutions in urology. Further research is needed to determine the full suitability of these advanced bioabsorbable devices.

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Drug-eluting bioabsorbable stents - an in vitro study.

Acta biomaterialia·2009

Area of Science:

  • Biomaterials Science
  • Urology
  • Polymer Engineering

Background:

  • Bioabsorbable polymers like polylactide (PLA) and polyglycolide (PGA) have been utilized since the 1970s for medical devices.
  • Self-reinforced (SR) devices, including spiral stents (SR-PGA, SR-PLLA, SR-PLA96), possess unique mechanical and degradation properties achieved through specialized processing.

Purpose of the Study:

  • To review the novel application of bioabsorbable devices, specifically spiral stents, in urology.
  • To discuss the current status and potential of SR-PGA, SR-PLLA, and SR-PLA96 spiral stents for various urethral and ureteral applications.
  • To highlight the need for further research into bioabsorbable stent materials and designs in urology.

Main Methods:

  • Review of existing literature on bioabsorbable polymers and their application in urology.

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  • Analysis of the properties and current uses of commercially available SR-PGA stents (Biofix).
  • Discussion of ongoing development and potential applications of SR-PLLA and SR-PLA96 stents.

    • Main Results:

    • Self-reinforced spiral stents exhibit significant expansion capabilities (up to 70% diameter increase) and variable degradation rates.
    • SR-PGA stents are commercially available for the prostatic urethra with specific indications, including post-thermal therapy and temporary relief of obstruction.
    • SR-PLLA and SR-PLA96 stents are under development for anterior urethra, prostatic urethra, and ureter applications.

    Conclusions:

    • Bioabsorbable spiral stents represent a novel and promising technology in urology.
    • Current applications of SR-PGA stents are established, while other variants show potential for broader use.
    • Extensive experimental and clinical studies are essential to fully evaluate the efficacy and safety of bioabsorbable urological devices.