Related Experiment Videos
Use of the Sensormedics MCT Accelerator in sputum induction
M A McClean1, P I Field, M J Matheson
1Department of Thoracic Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Respirology (Carlton, Vic.)
|December 1, 1996
Summary
The Sensormedics MCT Accelerator did not improve sputum production or cellular profile in subjects undergoing induced sputum analysis. This high-frequency oscillator device did not enhance saline-induced sputum yield in asthmatic or non-asthmatic individuals.
Area of Science:
- Respiratory Medicine
- Pulmonology
- Clinical Investigation
Background:
- Airway inflammation assessment often involves induced sputum analysis.
- Sputum induction typically uses inhaled hypertonic saline.
- Devices aimed at airway secretion clearance warrant investigation for their impact on sputum induction.
Purpose of the Study:
- To evaluate the efficacy of the Sensormedics MCT Accelerator in enhancing sputum production.
- To determine if the MCT Accelerator alters the cellular profile of induced sputum.
- To assess sputum induction in non-asthmatic non-atopic, atopic, and asthmatic subjects.
Main Methods:
- A crossover study design was employed over three days.
- Subjects underwent skin prick testing and methacholine challenge on day 1.
- Sputum induction was performed using 3% saline alone or with the MCT Accelerator on separate days.
Main Results:
- The MCT Accelerator did not significantly increase sputum volume.
- No significant changes were observed in the cellular profile of induced sputum.
- The device did not enhance the yield of sputum compared to saline alone.
Conclusions:
- The Sensormedics MCT Accelerator does not improve sputum production for diagnostic purposes.
- The device does not alter the cellular composition of induced sputum.
- Current methods of saline-induced sputum production remain unaffected by this oscillatory device.