[Destruction of the alveolar bone during development of periodontal disease]

The papers surveys the mechanisms of alveolar bone destruction in the course of parodontopathy development. The results obtained in the studies carried out so far have shown that human inflamed gingiva contains biologically active substance Interleukin-1 (IL-1), tumor necrosis factor and prostaglandin E2 in concentration which are high above the minimal values that can induce in vitro the bone resorption. It has been generally understood that alveolar bone destruction is a result of the increased osteoclastic activity caused by the synchronous effect of mentioned mediators released from the structural cells and cells of inflamed infiltrate into the bone tissue encircling.