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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Effect of HMGcoA reductase inhibitors on stroke. A meta-analysis of randomized, controlled trials

H C Bucher1, L E Griffith, G H Guyatt

  • 1Kantonsspital Basel, Switzerland.

Annals of Internal Medicine
|January 24, 1998
PubMed

Insights

HMGCoA reductase inhibitors significantly reduce stroke risk in hyperlipidemic patients. This cholesterol-lowering intervention also lowers coronary heart disease deaths and overall mortality.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Epidemiology

Background:

  • Stroke is a major cause of death globally.
  • Hypercholesterolemia is a potential risk factor for stroke.

Purpose of the Study:

  • To evaluate if cholesterol reduction using HMGCoA reductase inhibitors or other antilipidemic treatments lowers stroke risk.
  • To assess the impact on nonfatal and fatal strokes.

Main Methods:

  • Systematic literature search of MEDLINE and EMBASE databases (1966-1996).
  • Inclusion of 28 randomized controlled trials (49,477 intervention, 56,636 control participants).
  • Analysis of trials reporting stroke, coronary heart disease, and mortality data.

Main Results:

  • HMGCoA reductase inhibitors showed a risk ratio of 0.76 for nonfatal and fatal stroke (95% CI, 0.62-0.92).
  • Other interventions (fibrates, resins, diet) had risk ratios near 1.0.
  • Significant difference observed between HMGCoA inhibitor effect and other interventions (P=0.01).
  • HMGCoA reductase inhibitors also reduced coronary heart disease mortality and overall mortality.

Conclusions:

  • HMGCoA reductase inhibitors are effective in reducing stroke incidence in hyperlipidemic patients without prior stroke.
  • This meta-analysis supports the use of HMGCoA reductase inhibitors for stroke prevention in this population.
Abstract

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