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Related Experiment Videos

Regional mapping panels for chromosomes 3, 4, 5, 11, 15, 17, 18, and X

J C Leonard1, H L Drwinga, C H Kim

  • 1NIGMS Human Genetic Mutant Cell Repository, Coriell Cell Repositories, Coriell Institute for Medical Research, Camden, New Jersey 08103, USA.

Genomics
|January 27, 1998
PubMed
Summary

The NIGMS Repository provides human/rodent somatic cell hybrid panels for mapping specific human chromosomes. These well-characterized panels divide chromosomes into distinct intervals for genetic research.

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Area of Science:

  • Genetics
  • Cell Biology
  • Genomic Research

Background:

  • Accurate human chromosome mapping is crucial for understanding genetic diseases.
  • Somatic cell hybrids are valuable tools for regional chromosome analysis.
  • The NIGMS Human Genetic Mutant Cell Repository plays a key role in providing essential research resources.

Purpose of the Study:

  • To provide researchers with well-characterized regional mapping panels for human chromosomes.
  • To facilitate the precise localization of genes and genetic alterations on specific chromosomes.
  • To support genetic studies by offering a standardized resource for chromosome analysis.

Main Methods:

  • Collection and distribution of human/rodent somatic cell hybrid panels.
  • Characterization of hybrid panels to define chromosome intervals.

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  • Utilizing panels covering human chromosomes 3, 4, 5, 11, 15, 17, 18, and X.

    • Main Results:

    • Established regional mapping panels for multiple human chromosomes.
    • Each panel comprises 4 to 11 hybrids, dividing chromosomes into 5 to 11 intervals.
    • Panels are extensively validated by submitters and the NIGMS Repository.

    Conclusions:

    • The NIGMS Repository offers a vital resource for high-resolution human chromosome mapping.
    • These somatic cell hybrid panels enable precise genetic locus determination.
    • The characterized panels support diverse genetic and genomic research applications.