Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A circular code in the protein coding genes of mitochondria

D G Arquès1, C J Michel

  • 1Equipe de Biologie Théorique, Université de Marne la Vallée, Institut Gaspard Monge, 2 rue de la Butte Verte, 93160 Noisy le Grand, France. arques@univ-mlv.fr

Journal of Theoretical Biology
|February 28, 1998
PubMed
Summary

Researchers identified a novel maximal circular code, X0(MIT), within mitochondrial protein-coding genes. This code and its permutations (X1(MIT), X2(MIT)) exhibit unique properties influencing gene reading frames and nucleotide composition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sport science for salmon and other species: ecological consequences of metabolic power constraints.

Ecology letters·2015
Same author

A computer method for identifying patterns in electroencephalogram signals.

Journal of medical engineering & technology·2003
Same author

[Determinants of long-term follow-up after stent implantation in acute myocardial infarction].

Zeitschrift fur Kardiologie·2002
Same author

Analysis of a circular code model.

Journal of theoretical biology·2002
Same author

Risk factors for the development of restenosis following stent implantation of venous bypass grafts.

Heart (British Cardiac Society)·2001
Same author

[Operation or angioplasty in coronary heart disease--a summary of prospective randomized studies].

Deutsche medizinische Wochenschrift (1946)·2001

Area of Science:

  • Genetics
  • Molecular Biology
  • Bioinformatics

Background:

  • Mitochondrial genomes contain protein-coding genes that are translated using a genetic code.
  • Understanding the intricacies of gene expression and reading frame maintenance is crucial for deciphering mitochondrial function.

Purpose of the Study:

  • To identify and characterize novel maximal circular codes within mitochondrial protein-coding genes.
  • To analyze the properties and implications of these codes on gene reading frames.

Main Methods:

  • Identification of maximal circular codes (X0(MIT), X1(MIT), X2(MIT)) in mitochondrial protein-coding genes.
  • Analysis of trinucleotide composition and frequency within identified codes.
  • Evaluation of code properties related to reading frame retrieval and nucleotide distribution.

Related Experiment Videos

Main Results:

  • A new maximal circular code, X0(MIT), was identified, along with two circularly permuted versions, X1(MIT) and X2(MIT), corresponding to reading frames 0, 1, and 2.
  • X0(MIT) demonstrates a minimal window of five nucleotides for automatic frame 0 retrieval.
  • The code exhibits a low probability of misplaced trinucleotides (12%) in shifted frames and specific nucleotide occurrence patterns.

Conclusions:

  • The identified maximal circular codes play a role in maintaining reading frame integrity in mitochondrial genes.
  • The unique properties of X0(MIT) contribute to the accuracy of protein translation within mitochondria.
  • Further investigation into the biological consequences of these codes is warranted.