Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene expression and development databases for C. elegans

Martinelli1, Brown, Durbin

  • 1Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

Seminars in Cell & Developmental Biology
|January 27, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Positions and Intensities in the 2nu4/nu1/nu3 Vibrational System of 14NH3 Near 3 µm.

Journal of molecular spectroscopy·1999
Same author

Proximate and ultimate causes of adoption in ring-billed gulls.

Animal behaviour·1999
Same author

Research: The Effect of Wetland Mitigation Banking on the Achievement of No-Net-Loss.

Environmental management·1999
Same author

Response

Gastrointestinal endoscopy·1999
Same author

Manipulation of in vivo sorbitol production alters boron uptake and transport in tobacco

Plant physiology·1999
Same author

Biochemical analysis of plant protection afforded by a nonpathogenic endophytic mutant of colletotrichum magna

Plant physiology·1999

The nematode Caenorhabditis elegans (C. elegans) offers a transparent model for studying gene expression during development. Data is stored in the ACeDB database, linked to biological features and developmental stages, aiding research and genome projects.

Area of Science:

  • Developmental Biology
  • Genomics
  • Bioinformatics

Background:

  • The nematode worm Caenorhabditis elegans (C. elegans) is a valuable model organism due to its transparent body, facilitating the study of developmental gene expression.
  • Comprehensive expression data is crucial for understanding embryogenesis and the organism's life cycle.

Purpose of the Study:

  • To consolidate and disseminate C. elegans gene expression data.
  • To create a linked database for gene expression patterns, associated biological entities, and developmental stages.
  • To develop tools for visualizing and analyzing this data.

Main Methods:

  • Utilizing in-situ hybridization, immunolocalization, and reporter constructs to gather gene expression data.
  • Storing and organizing data within the ACeDB database.

Related Experiment Videos

  • Developing the 'Angler' program for image and data visualization.

    • Main Results:

    • Gene expression patterns are systematically linked to genes, sequences, cells, organs, and developmental stages within the ACeDB database.
    • The ACeDB database serves as a central repository for C. elegans data, supporting genome sequencing initiatives.
    • 'Angler' allows browsing of embryonic development images correlated with cell lineage and positional data.

    Conclusions:

    • The integrated ACeDB database and 'Angler' program provide a powerful resource for C. elegans research.
    • This system enhances the study of developmental gene expression and facilitates genomic analysis.
    • The accessibility of linked expression data supports a deeper understanding of worm development.