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Efficacy of eprinomectin against Hypoderma spp in cattle
J E Holste1, D D Colwell, R Kumar
1Merck & Co Inc, Rahway, NJ 07065, USA.
American Journal of Veterinary Research
|January 27, 1998
Summary
Topical eprinomectin at 500 micrograms/kg demonstrated high efficacy against all Hypoderma spp. larval stages in cattle. This safe and effective treatment offers a no-withdrawal option for controlling cattle grubs.
Area of Science:
- Veterinary Parasitology
- Bovine Medicine
- Dermatology
Background:
- Hypoderma spp. cause significant economic losses in cattle due to hide damage and reduced productivity.
- Effective control of cattle grubs is essential for maintaining herd health and profitability.
Purpose of the Study:
- To evaluate the efficacy of a topical eprinomectin formulation against various larval stages of Hypoderma spp. in cattle.
- To assess the safety and clinical relevance of eprinomectin treatment for cattle grub infestations.
Main Methods:
- 140 cattle naturally infested with Hypoderma spp. were treated with topical eprinomectin (500 micrograms/kg) targeting first-stage (L1) or second/third-stage (L2/L3) larvae.
- Control groups received no treatment or vehicle treatment.
- Warble resolution time and larval viability were assessed.
Main Results:
- Eprinomectin achieved complete efficacy against L1 larvae and near 100% efficacy against L2/L3 larvae.
- Warbles resolved significantly faster in treated cattle compared to controls.
- No adverse reactions were observed during the trials.
Conclusions:
- Topical eprinomectin (500 micrograms/kg) is safe and highly effective for treating all larval stages of Hypoderma spp. in cattle.
- The formulation's attributes allow for treatment across all cattle classes without meat or milk withdrawal periods.